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PHARMACEUTICAL ENGINEERING

2011-04-28T23:26:00.001-07:00

Table of Contents: Articles

Increased Process Understanding Through Monitoring and Scale-Down Models: Case Study of a Cell Culture Harvest Fluid Titration and Filtration Process
by Kurt Yanagimachi, Corey Dodge, and Marisa Hewitt
This article presents a case study demonstrating the use of detailed process monitoring and scale-down modeling in determining the root causes of yield losses in the manufacture of a therapeutic enzyme and identifying alternative technologies to improve the manufacturing process.
Case Study: Parenteral Facility Upgrade Project with Fill Line Install
by Keith Weseli and Michael DiGiovanni
This article presents a case study illustrating project management and commissioning and qualification processes that allowed for accelerated completion of a renovation project.
Integrating Industrial Engineering and Lean Techniques at a Contract Pharmaceutical Manufacturer
by Valerie Maier-Speredelozzi, Cyrus Agarabi, Thomas Needham, and Sirine A. Saleem
This article presents the application of industrial engineering and lean techniques to a contract pharmaceutical manufacturing facility.
Retrofitting CIP into API Plants
by Nigel A. Fletcher
This article describes the physical modifications and additions retrofitted into existing plants to incorporate CIP technology and some of the techniques that can be used to ‘stretch’ the existing CIP systems for best effect.
Solving the Terminology Conundrum
by Robert Adamson, Nuala Calnan, Robert E. Chew, and Steven J. Wisniewski
This article discusses the terms “commissioning,” “qualification,” and “verification.” Do the terms refer to the same or different ideas? How should the pharmaceutical and biotechnology industries use these terms in a consistent and meaningful way? This article provides a compilation of how these terms are used in regulations and by various industries, and provides a proposal for clear definitions to be used as ISPE updates and creates Baseline® Guides.

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NATURE GENETICS

2011-04-28T03:49:00.000-07:00

Click on the links for access to the journal

May 2011 Volume 43 Number 5, pp 389 - 499

Visit Nature Genetics online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=131&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0

Please note that you need to be a subscriber to enjoy full text access
to Nature Genetics online. To purchase a subscription, please visit:
http://links.ealert.nature.com/ctt?kn=72&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0

Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.com/ctt?kn=47&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0

GENOMIC Know-How. Discovery is all about pushing the boundaries of
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http://links.ealert.nature.com/ctt?kn=19&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0

See the Light. Make the Switch. Stop Cloning!
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http://links.ealert.nature.com/ctt?kn=120&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0

12th INTERNATIONAL CONGRESS OF HUMAN GENETICS

ASHG and the IFHGS invite you to the 12th International Congress
of Human Genetics (ICHG), on October 11-15, 2011, in Montreal,
Canada. Submit an abstract, apply for a travel grant, and register
to attend the largest human genetics meeting ever with more than
7,500 of your colleagues from around the world.
http://links.ealert.nature.com/ctt?kn=98&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0

Nature Reviews Genetics
Focus on Gene-Based Therapies
http://links.ealert.nature.com/ctt?kn=8&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0

This Focus issue brings you up to date with progress in gene-based
therapies, including gene delivery using viral vectors, strategies
based on RNA-mediated silencing, and approaches that use stem and
progenitor cells. All articles in the Focus are available for free
for one month.

EDITORIAL
----------------------
No second thoughts about data access p389
doi:10.1038/ng.827
More data than we can handle is no excuse to give up our efforts to
promote data access, but it may make us think about new ways to make it sustainable.
http://links.ealert.nature.com/ctt?kn=74&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0

Variants modulating the expression of a chromosome domain encompassing PLAG1
influence bovine stature pp405 - 413
Latifa Karim et al.
doi:10.1038/ng.814
Michel Georges and colleagues report fine mapping and functional characterization
of a quantitative trait locus with a large effect on bovine stature. They show
that the likely causal variants at this locus modulate expression of a
chromosomal domain encompassing PLAG1 and several other genes.
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=91&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0

Variants modulating the expression of a chromosome domain encompassing PLAG1
influence bovine stature pp405 - 413
Latifa Karim et al.
doi:10.1038/ng.814
Michel Georges and colleagues report fine mapping and functional characterization
of a quantitative trait locus with a large effect on bovine stature. They show
that the likely causal variants at this locus modulate expression of a
chromosomal domain encompassing PLAG1 and several other genes.
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=91&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0

Glycerol-3-phosphate is a critical mobile inducer of systemic immunity in plants pp421 - 427
Bidisha Chanda et al.
doi:10.1038/ng.798
Pradeep Kachroo and colleagues show that glycerol-3-phosphate is a critical mobile
inducer of systemic acquired resistance in plants.
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=104&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0

Mutant nucleophosmin and cooperating pathways drive leukemia initiation
and progression in mice pp470 - 475
George S Vassiliou et al.
doi:10.1038/ng.796
George Vassiliou, Allan Bradley and colleagues perform a Sleeping Beauty
transposon mutagenesis screen to identify insertions that cooperate with
mutant Npm1 to produce acute myeloid leukemia (AML) in mice. They observed
mutually exclusive integrations in Csf2, Flt3 or Rasgrp1 in a high percentage
of cases, providing insights into the molecular pathogenesis of this AML subtype.
Abstract: http://links.ealert.nature.com/ctt?kn=124&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=53&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0

A framework for variation discovery and genotyping using next-generation
DNA sequencing data pp491 - 498
Mark A DePristo et al.
doi:10.1038/ng.806
Mark DePristo and colleagues report an analytical framework to discover
and genotype variation using whole exome and genome resequencing data
from next-generation sequencing technologies. They apply these methods
to low-pass population sequencing data from the 1000 Genomes Project.
Abstract: http://links.ealert.nature.com/ctt?kn=127&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=36557924&r=MzU0NzkwNjQwNAS2&b=2&j=MTAwMTY2NDYzS0&mt=1&rt=0

MCQs in Pharmaceutical Calculations

2011-04-05T06:29:00.000-07:00

MCQs in Pharmaceutical Calculations

This is a revision guide in calculations for pharmacy students and registration trainees. This text is part of the RPS "Tomorrow's Pharmacist" series. The

Drug Discovery and Evaluation: Pharmacological Assays

2009-10-22T06:27:00.000-07:00

The rapid progress in biology will continue to change the methodological approach to drug discovery in the coming years. Electronic media will continuously help researchers to access and share information. It is, however, becoming more and more evident that many young pharmacologists have only limited training in classical pharmacological methodologies. These long-standing and still highly relevant methods are simply not available in the electronic databases. Drug Discovery and Evaluation:Pharmacological Assays bridges this gap by comprehensively covering the pharmacological methods that have been utilized successfully for more than a hundred years as well as the latest technologies.

The classical methods and the newest technologies, all in one book!

The 3rd edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal, and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described.

For this third edition, all existing chapters have been revised and completely updated. A large number of assays were added: we are now publishing two volumes. Sections that have been specifically enlarged include - Pharmacological assays in thrombosis and haemostasis (formerly called activity of blood constituents), - Antidiabetic activity (includes completely new chapters such as Biochemical Methods in Diabetology), - Anti-atherosclerotic activity.

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Cocaine (Drugs: the Straight Facts)16

2009-10-02T01:02:00.000-07:00

Cocaine (Drugs: the Straight Facts) (US$30)
Stationary Office Pages: 112 2003-03 ISBN: 0791072606 10 MB
Cocaine is a very addictive drug. Cocaine is a stimulant it directly affects your brain. Cocaine stimulates certain nerve cells in the brain, producing feelings of intense pleasure. Users talk about feeling carefree, or relaxed, or utterly in control. But this artificial stimulation comes with a price tag. The “high” from cocaine lasts only from five to 20 minutes, and you will need more and more cocaine each time you try to match the feelings of that first, initial experience. Cocaine causes severe mood swings and irritability. As soon as cocaine enters your bloodstream it goes to work, increasing your heart rate and raising your blood pressure. It increases your body’s temperature and causes the pupils of your eyes to dilate. Repeated sniffing of cocaine powder causes your nose to become irritated and frequently runny. The cocaine can even eat away at the cartilage in your nose, producing holes.

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Non-Prescription Medicines 2nd Edition

2009-10-02T00:52:00.000-07:00

This revised edition assesses the range of non-prescription, over-the-counter medicines that can be recommended for the most frequently encountered minor illnesses. The first edition has been updated to reflect changes in the legal status and availability of products and new opinions on and approaches to treatment. A new section on emergency hormonal contraception is also included. The information is presented in a structured formulary format with products described both generically and by brand name along with supplier details. Each chapter also contains a summary of key points with suggestions regarding the most appropriate products. The book should enable pharmacists, GPs, nurses and other healthcare professionals to make well-informed recommendations and to give patients and customers sound advice on non-prescription medicines.

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Applied Thin Layer Chromatography

2009-09-28T19:35:00.000-07:00

Thin layer chromatography (TLC) is a powerful, fast and inexpensive analytical method. It has proven its usefulness in pharmaceutical, food and environmental analysis. This new edition features a completely revised chapter on documentation, now including the use of digital cameras. Selected new sorbents and instruments are also introduced.Why has the prior edition been successful? All steps of the analytical procedure are freeduan.com clearly explained, starting with the choice of a suitable TLC technique and ending with data evaluation and documentation. Special emphasis is put on the proper choice of materials for TLC. Properties and functions of various materials and the TLC equipment are described, covering e. g. precoated layers, solvents and developing chambers, and including information on suppliers. Many practical hints for trouble shooting are given. All this is illustrated with numerous coloured figures.

How to use TLC in compliance with GLP/GMP regulations is described in detail, including the required documentation. Therefore the reader can very easily compile his own standard operating procedures.

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Multidimensional Chromatography

2009-09-28T19:34:00.000-07:00

Concentrates on the broad field of multidimensional chromatography and its applications in various areas, including pharmaceutical, industrial, environmental, biological and petroleum.

Presents information for using multidimensional chromatography in the analytical laboratory. Contains invaluable information put together from the experience and research activities of the

authors including Keith Bartle - a pioneer in multidimensional chromatography.
First book to discuss all multidimensional techniques
Covers a subject area that is part of the exploding field of hypenated techniques
Includes a general introduction to all areas of the subject followed by applications

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Enantiomer Separation: Fundamentals and Practical Methods

2009-09-28T19:33:00.000-07:00

Enantiomer Separation is written by several experts working in modern enantiomer separation chemistry who understand the needs of the many scientific and engineering chemists who need a cost-efficient supply of optically active materials of high quality. This book contains the following modern practical methods of enantiomer separation: Inclusion complexation of a racemic compound with a chiral host compound, which gives chiral host-chiral guest inclusion compounds, from which the chiral guest can be obtained. When this separation is combined with distillation technique, for example, enantiomer separation can be accomplished by fractional distillation in the presence of a chiral host compound. This is a modern and "green" procedure of enantiomer separation. These separation methods are described in several chapters of the book. Biological separation methods and "green" methods are covered in two chapters. Enantiomer separation by chromatography on a column containing chiral solid phase is one of the most up-to-date and well known "green" methods of enantiomer separation. Two experts in chromatography have contributed to provide two very important chapters on this method of separation. Practical methods of enantiomer separation are important both in the research laboratory and in industry, especially in the pharmaceutical, fine chemical and electronic industries. Chemists and engineers, as well as students who are working in the field of chiral compounds in universities, institute and industry, will find this book an invaluable resource.

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A Century of Separation Science

2009-09-28T19:32:00.000-07:00

A Century of Separation Science presents an historical, as well as technical, perspective of the critical developments in separation science since 1900, covering recent advances in chromatography, electrophoresis, field-flow fractionation, countercurrent chromatography, and supercritical fluid chromatography for high-speed and high-throughput analysis. The author also discusses the theory of gradient elution and solvent selection for optimal separation in liquid chromatography.

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Advances in Chromatography Volume 46

2009-09-28T19:31:00.000-07:00

Publisher: CRC
Number Of Pages: 488
Publication Date: 2007-11-05
ISBN-10 / ASIN: 1420060252
ISBN-13 / EAN: 9781420060256
Binding: Hardcover

Written by leading international experts in academia and industry, Advances in Chromatography, Volume 46 presents all new chapters with thorough reviews on the latest developments in the field.

Volume 46 includes new advances in two-dimensional gas chromatography, reversed phase liquid chromatography/shape selectivity, and supercritical fluid chromatography. The book highlights enantioselective separations with emphasis on chiral recognition mechanisms, screening approaches, and separation speed. It also emphasizes hyphenated techniques and enhanced fluidity chromatography with emphasis on monolithic organo-silica hybrid columns. This volume provides an excellent starting point for gaining quick knowledge to the field of separation science.

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HPLC Made to Measure: A Practical Handbook for Optimization

2009-09-28T19:29:00.000-07:00

The only topical HPLC book to focus on optimization, this volume addresses the needs of HPLC users who wish to constantly improve their methods, in particular in terms of throughput, accuracy and cost-effectiveness.
This handbook features contributions from such bestselling authors as John W. Dolan, Michael McBrien, Veronika R. Meyer, Uwe D. Neue, Lloyd R. Snyder, and Klaus K. Unger, as well as from scientists working for major companies, including Agilent, AstraZeneca, Merck, Schering, Tosoh Biosep, VWR, and Waters. It covers essential aspects of optimization in general, optimization in different LC-modi, hyphenated techniques and computer-aided optimization. The whole is rounded off with a section of user reports.

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Handbook of Separation Process Technology

2009-09-28T19:28:00.000-07:00

Surveys the selection, design, and operation of most of the industrially important separation processes. Discusses the underlying principles on which the processes are based, and provides illustrative examples of the use of the processes in a modern context. Features thorough treatment of newer separation processes based on membranes, adsorption, chromatography, ion exchange, and chemical complexation. Includes a review of historically important separation processes such as distillation, absorption, extraction, leaching, and crystallization and considers these techniques in light of recent developments affecting them.

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Ion Chromatography

2009-09-28T19:27:00.000-07:00

Ion Chromatography, 2E
By Joachim Weiss

Publisher: Vch Verlagsgesellschaft Mbh
Number Of Pages: 466
Publication Date: 1994-12
ISBN-10 / ASIN: 3527286985
ISBN-13 / EAN: 9783527286980

This all-new edition of the highly successful first edition contains a wealth of up-to-date information on this major analytical technique. Ion-exchange, ion-exclusion, and ion-pair chromatography are treated together with their detection methods, and a discussion of quantitative analysis is also given. The complete range of application possibilities of this technique is described and illustrated with numerous chromatograms. Special chapters are featured on applications in environmental analysis, clinical chemistry as well as in the food and beverage industry.

From reviews of previous editions:
This volume can be highly recommended to both the experienced user and the newcomer in the field of ion chromatography. Zeitschrift fuer Wasser- und Abwasserforschung

Everybody who is actively dealing with ion chromatography cannot afford to miss this book. Laborpraxis

This book is a valuable aid to all scientists wishing to work confidently with these different methods, as well as practitioners who employ these techniques on a day-to-day basis.

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Chromatography Theory (Chromatographic Science, Vol. 88)

2009-09-28T19:26:00.000-07:00

This title presents a comprehensive overview of the principles, methods and fundamental theories used in the separation, quantification and analysis of individual compounds and substances. It identifies recent advances, mathematical relationships and useful design techniques for optimal system operation and control of chemical and chromatographic processes.

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Illustrated Pocket Dictionary of Chromatography

2009-09-28T19:24:00.000-07:00

Provides concise definitions, illustrations, formulas, and all of the other information that you need in a laboratory chromatography reference

The Illustrated Pocket Dictionary of Chromatography offers the perfect quick reference to the parameters, systems, and components that support successful chromatographic separations. Concise, practical, and filled with detailed drawings, diagrams, and photographs, this pocket dictionary is designed for easy use in the laboratory. It provides a complete, up-to-date reference on analytical techniques such as gas chromatography, high-performance liquid chromatography, thin layer chromatography, and capillary electrophoresis as well as preparation techniques such as solid phase extraction and microextraction.

The Illustrated Pocket Dictionary of Chromatography features:

Explanations of key concepts
Equations and formulas
Parameters
High-quality photographs of instruments, equipment, and components
References for further research
Explanations of common acronyms

Ideal for the working chemist or technician in pharmaceutical, industrial, forensic, government, or other lab settings, the Illustrated Pocket Dictionary of Chromatography is also appropriate as a supplemental reference for analytical chemistry courses and labs. Students and analysts alike will find this compact yet comprehensive resource a valuable companion to their work in chromatography.

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Filtration in the Biopharmaceutical Industry

2009-09-28T19:22:00.000-07:00

This timely resource offers comprehensive examinations of the most recent developments in the field, from prefiltration methods to final, gas, and tangential flow filtration techniques. Delineates filtration in a host of applications, including virus removal, protein binding, and sterility testing and introduces new, membrane-based technologies for the biopharmaceutical industry! Addressing quality, security, economic, process development, and regulatory topics, Filtration in the Biopharmaceutical Industry presents pre- and sterility grade filters, charge-modified filter media, and aids to filtration discusses filter quality assurance, pore size, extractables, and compatibilities in various filters examines filter design and construction analyzes integrity testing, test sensitivity, and automation furnishes novel filtration flow methods explains filter validation summarizes the U.S. Food and Drug Administration regulations governing filtration and more!

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Biopharmaceutics and Pharmaceutical Calculations Tutorials - Australian Pharmacy Examining Council

2009-09-28T19:20:00.000-07:00

Two computer based educational modules were developed using the authoring package ToolBook Multimedia CBT Edition (Asymetrix Corporation), operating on a Windows® platform, and distributed on disk. They included tuition and assessment in the areas of pharmaceutical calculations (M1) and biopharmaceutics (M2) and were aimed at assisting overseas qualified pharmacists preparing for an Australian registration exam. Presented are the results of evaluations for the assessment programs' level of achievement of set educational objectives, frequency and patterns of use. Respondents (n=32) rated 'high-very high' the extent to which the following objectives were met: encouragement of testing of tutorial knowledge (M1: 90.3%; M2: 90.0%); provision of practice using the examination question format (M1: 90.0%; M2: 96.5%); encouragement of review of tutorials based on test performance (M1: 83.9%; M2: 86.7%). The analysis of data disks (n=58) on assessment program use indicated: total tests: (M1: 1,713; M2: 1,152); questions attempted: (M1: 20,900; M2: 15,921); timer option used: this was selected in 36.9% of total tests; period of testing with timer (118.4h) and without timer (598.1h) (maximum allowable question time recorded). Overall, the assessment programs were found very valuable components of each module. They were perceived to have met their set objectives and were significantly used.

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Biopharmaceutical Process Validation

2009-09-28T19:18:00.000-07:00

A study of biopharmaceutical process validation. It aims to enable developers and producers to ensure safe products, reduce the risk of adverse reactions in patients, and avoid recalls by outlining sophisticated validation approaches to characterize processes, process intermediates, and final product fully. The text emphasizes cost effectiveness while determining what level of validation is required for different phases of development, license application, and process improvements.

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Developing Solid Oral Dosage Forms: Pharmaceutical Theory&Practice

2009-09-28T19:15:00.000-07:00

This book is intended for pharmaceutical professionals engaged in research and development of oral dosage forms. It covers essential principles of physical pharmacy, biopharmaceutics and industrial pharmacy as well as various aspects of state-of-the-art techniques and approaches in pharmaceutical sciences and technologies along with examples and/or case studies in product development. The objective of this book is to offer updated (or current) knowledge and skills required for rational oral product design and development. The specific goals are to provide readers with:

Basics of modern theories of physical pharmacy, biopharmaceutics and industrial pharmacy and their applications throughout the entire process of research and development of oral dosage forms

Tools and approaches of preformulation investigation, formulation/process design, characterization and scale-up in pharmaceutical sciences and technologies

New developments, challenges, trends, opportunities, intellectual property issues and regulations in solid product development

The first book (ever) that provides comprehensive and in-depth coverage of what's required for developing high quality pharmaceutical products to meet international standards

It covers a broad scope of topics that encompass the entire spectrum of solid dosage form development for the global market, including the most updated science and technologies, practice, applications, regulation, intellectual property protection and new development trends with case studies in every chapter

A strong team of more than 50 well-established authors/co-authors of diverse background, knowledge, skills and experience from industry, academia and regulatory agencies.

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Principles and Practices of Method Validation Proceedings

2009-09-27T18:52:00.000-07:00

Principles and Practices of Method Validation is an overview of the most recent approaches used for method validation in cases when a large number of analytes are determined from a single aliquot and where a larege number of samples are to be analysed. Much of the content relates to the validation of new methods for pesticide residue analysis in foodstuffs and water but the principles can be applied to other similar fields of analysis. Different chromatographic methods are discussed, including estimation of various effects, eg. matrix-induced effects and the influence of the equipment set-up. The methods used for routine purposes and the validation of analytical data in the research and development environment are documented. The legislation covering the EU-Guidance on residue analytical methods, an extensive review of the existing in-house method validation documentation and guidelines for single-laboratory validation of analytical methods for trace-level concentrations of organic chemicals are also included. With contributions from experts in the field, any practising analyst dealing with method validation will find the examples presented in this book a useful source of technical information.

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Analytical Measurement Terminology: Handbook of Terms Used in Quality Assurance of Analytical Measurement

2009-09-27T18:51:00.000-07:00

This unique handbook explains the most commonly used terminology and places each term in context. Concepts are described in a way that make them meaningful to practitioners and in line with "official definitions" developed by international organizations.

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Bioanalytical Separations, Volume 4

2009-09-27T18:50:00.000-07:00

Bioanalytical Separations is volume 4 of the multi-volume series, Handbook of Analytical Separations, providing reviews of analytical separation methods and techniques used for the determination of analytes across a whole range of applications. The theme for this volume is bioanalysis, in this case specifically meaning the analysis of drugs and their metabolites in biological fluids.

- Discusses new developments in instrumentation and methods of analyzing drugs and their metabolites in biological fluids

- Provides guidance to the different methods, their relative value to the user, and the advantages and pitfalls of their use

- Future trends are identified, in terms of the potential impact of new technologies.

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Handbook of Basic Tables for Chemical Analysis, Second Edition

2009-09-27T18:48:00.000-07:00

If you are a researcher in organic chemistry, chemical engineering, pharmaceutical science, forensics, or environmental science, you make routine use of chemical analysis. And like its best-selling predecessor was, the Handbook of Basic Tables for Chemical Analysis, Second Edition is your one-stop source for the information needed to design chemical analyses. Here's what is new in the Second Edition:"New chapters on solutions, electroanalytical methods, electrophoresis, and laboratory safety"An expanded section on gas chromatography that includes data on compounds that attack common detectors"New information on detector optimization"An updated section on high performance liquid chromatography that provides the most recent chiral stationary phases, detector information, and revised solvent tables"Updated information on the most useful "wet" chemistry methods"Enlarged section of Miscellaneous Tables Going far beyond the landmark first edition in terms of scope and applications, the second edition provides current and updated data culled from a wide range of resources and consolidated into a concise yet easy-to-use format. The book's laser-like focus on core information gives you the knowledge you need when you need it - at the decision point.

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Instant Notes in Analytical Chemistry

2009-09-27T18:47:00.000-07:00

Instant Notes in Analytical Chemistry provides concise yet comprehensive coverage of analytical chemistry at an undergraduate level, providing easy access to the core information in the field. The book covers all the important areas of analytical chemistry in a format which is ideal for learning and rapid revision.

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Cyclodextrins and Their Complexes: Chemistry, Analytical Methods, Applications

2009-09-27T18:41:00.000-07:00

Offering comprehensive and up-to-date know-how in one compact book, an experienced editor and top authors cover every aspect of these important molecules from molecular recognition to cyclodextrins as enzyme models.

Chapters include reactivity and chemistry, chromatography, X-ray, NMR plus other physicochemical methods, as well as model calculations, rotaxane and catenane structures, and applications in the pharmaceutical industry. The book also discusses other applications such as in the cosmetics, toiletries, textile and wrapping industries, agrochemistry, electrochemical sensors, and devices.

A must for everyone working with these substances.

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Analytical Determination of Nicotine and Related Compounds and their Metabolites

2009-09-27T18:30:00.000-07:00

This book provides for the first time a single comprehensive source of information on the analytical chemistry of nicotine and related alkaloids. The editors have brought together scientists from academia and the tobacco industry to describe the state-of-the-art of the chemistry and analytical methods for measurement of nicotine. Both the scope and detail of the book are impressive. Chapters describe the history, pharmacology and toxicology of nicotine, the biosynthesis of nicotine and other alkaloids in the tobacco plant, the general chemistry of nicotine and the analytical methodologies that have been used to measure nicotine and related alkaloids in biological specimens, in tobacco and pharmaceutical products and in tobacco smoke. There is also a comprehensive review of the chemistry and toxicology of nicotine-derived nitrosamines, an important class of tobacco carcinogens.

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Quality Assurance in Analytical Chemistry

2009-09-27T18:28:00.000-07:00

The issue of quality assurance in the analytical chemistry laboratory has become of great importance in recent years.

Quality Assurance in Analytical Chemistry introduces the reader to the whole concept of quality assurance. It discusses how all aspects of chemical analysis, from sampling and method selection to choice of equipment and the taking and reporting of measurements affect the quality of analytical data. Finally, the implementation and use of quality systems are covered.

The issue of quality assurance in the analytical chemistry laboratory has become of great importance in recent years.

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Introduction to Mass Spectrometry: Instrumentation, Applications, and Strategies for Data Interpretation

2009-09-27T18:27:00.000-07:00

Completely revised and updated, this text provides an easy-to-read guide to the concept of mass spectrometry and demonstrates its potential and limitations. Written by internationally recognised experts and utilising "real life" examples of analyses and applications, the book presents real cases of qualitative and quantitative applications of mass spectrometry. Unlike other mass spectrometry texts, this comprehensive reference provides systematic descriptions of the various types of mass analysers and ionisation, along with corresponding strategies for interpretation of data. The book concludes with a comprehensive 3000 references.

This multi-disciplined text covers the fundamentals as well as recent advance in this topic, providing need-to-know information for researchers in many disciplines including pharmaceutical, environmental and biomedical analysis who are utilizing mass spectrometry.

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Gas Chromatography: Analytical Chemistry by Open Learning, 2nd Edition

2009-09-27T18:16:00.000-07:00

Approaches the subject from the perspective of a chromatographer who needs to know enough theory to make the best use of a chosen technique. Emphasizes the actual application of the methods--not just the theories on which they are based. This edition features a number of advances in the field since publication of the first volume. These include new chapters on high resolution gas chromatography (GC), GC detectors and classification of GC. Self-assessment questions ensure full understanding of the concepts.

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An Introduction to Aqueous Electrolyte Solutions

2009-09-27T18:09:00.000-07:00

An Introduction to Aqueous Electrolyte Solutions is a comprehensive coverage of solution equilibria and properties of aqueous ionic solutions. Acid/base equilibria, ion pairing, complex formation, solubilities, reversible emf’s and experimental conductance studies are all illustrated by many worked examples. Theories of non-ideality leading to expressions for activity coefficients, conductance theories and investigations of solvation are described; great care being taken to provide detailed verbal clarification of the key concepts of these theories. The theoretical development focuses on the physical aspects, with the mathematical development being fully explained. An overview of the thermodynamic background is given.

Each chapter includes intended learning outcomes and worked problems and examples to encourage student understanding of this multidisciplinary subject.

An invaluable text for students taking courses in chemistry and chemical engineering. This book will also be useful for biology, biochemistry and biophysics students who may be required to study electrochemistry as part of their course.

A comprehensive introduction to the behaviour and properties of aqueous ionic solutions, including clear explanation and development of key concepts and theories
Clear, student friendly style clarifying complex aspects which students find difficult
Key developments in concepts and theory explained in a descriptive manner to encourage student understanding
Includes worked problems and examples throughout.

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Modern Analytical Chemistry

2009-09-27T18:08:00.000-07:00

Modern Analytical Chemistry is a one-semester introductory text that meets the needs of all instructors. With coverage in both traditional topics and modern-day topics, instructors will have the flexibilty to customize their course into what they feel is necessary for their students to comprehend the concepts of analytical chemistry.

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Handbook of Instrumental Technique for Analytical Chemistry

2009-09-27T18:06:00.000-07:00

Chemical Analysis is not just for analytical chemists!

Scientists, engineers, and technicians in a variety of fields often need information from chemical analyses in their work. Many professional chemists also require information from techniques outside their area of specialization.

With this handbook, these users can find information about the most common analytical chemical techniques in an understandable form, simplifying decisions about which analytical techniques can provide the information they are seeking on chemical composition and structure.

Compiled by experts in each specialty, the handbook uses a standardized format to facilitate the comparison of techniques. Each chapter features:

* A quick-look summary
* How the technique works
* What information the technique can provide and how it's used
* Economic considerations
* Routine operational characteristics
* Reference sources for more detailed study
* A comprehensive glossary defines technical terms and acronyms.

The handbook covers widely used techniques in the areas:

* Electromagnetic spectrometry
* Separation techniques
* Mass spectrometry
* Electrochemistry
* Microscopy and surface techniques
* Polymers and macromolecules

A general introductory section addresses issues associated with:

* The process of obtaining chemical information from samples
* Preparation of organic and inorganic samples
* Accessing the quality of measurements
* Laboratory automation
* Laboratory information systems

Persons in areas such as biotechnology, materials science, environmental science, and geology will find the Handbook provides an understandable overview and useful introduction to techniques that can provide information to solve problems. The Handbook's wide range and standardized format make it the ideal reference work for anyone who uses chemical analyses in their work.

The enclosed Technique Selection Program can be used in two ways. In the first mode, users follow a series of menus to describe both the characteristics of their samples and the information they desire from the sample. They then receive a reference to appropriate analysis techniques described in the text. In the second mode, they can select from a listing of the techniques discussed in the book to obtain quick information about each method's applicability, including the characteristics of samples it can analyze, and the types of information the analysis provides.

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HVAC Equations, Data and Rules of Thumb

2009-09-27T18:04:00.000-07:00

The most complete, most job-critical reference for the most frequently used HVAC design data describes HVAC Equations, Data, Rules of Thumb. Veteran HVAC designer Arthur Bell Jr.'s handy, superbly organized data bank follows the CSI MasterFormat.

You'll reach for this time-saving task-simplifier dozens of times every working day for: Equations - more than 216 equations for everything from ductwork to air change rates...from steel pipe, relief valve and water heater sizing to NPSH calculations, Data definitions, ASME and ASHRAE code specs, air and waterproperties, conversion factors, building construction business fundamentals, equipment manufacturers, energy conservation conditions, auxiliary equipment, designer's checklists, professional societies and organizations, and more. 358 Rules of Thumb in all for buildings of every imaginable type, from churches to cocktail lounges. Includes cooling and heating loads, infiltration, ventilation, humidification, people/occupancy, lighting,appliance/equipment, more.

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A Pharmacology Primer, Third Edition: Theory, Application and Methods

2009-09-27T17:51:00.000-07:00

This successful guide assists scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. This latest edition continues the tradition of better preparing researchers in the basics of pharmacology. With expanded hands-on exercises and the addition of Pharmacokinetics coverage, new human interest material including historical facts in pharmacology and a new section on therapeutics that will help readers identify with diseases and drug treatments.

The ideal book for researchers in drug discovery who have seen their role shift from "individual" to "team player" where that team includes chemists, biologists, and others with strong, but varied, science backgrounds who must now work together toward their common pharmacology goal.

At GlaxoSmithKline, a pharmaceuticals world-leader, Terry Kenakin regularly teaches a course for their research scientists and has drawn on his experience to create a pharmacology primer.

*New - Latest coverage of the chemistry of drugs including expanded coverage of the pharmacokinetic discussion of druglike properties -- Increases reader understanding of necessary ADME (Absorption, Distribution, Metabolism, and Excretion) properties and increases the rate of drug approval and acceptance.

*Context - Unique discussions on various drug discovery teams and the role of the chemist on those teams -- Promotes the understanding of these expanding roles and responsibilities and how to maximize the effective contributions of each matrix team member.

*Real-world learning - There are hands-on exercises, with extensive answers, utilizing real data on structure activity relationships; utilization of pharmacological principles to make general statements about how changes in structure lead to changes in drug activity. + hands on exercises with extensive answers on Pharmacokinetics -- Stengthens practical application and understanding of core concepts and principles.

*Study sections are organized with ASPET (American Society for Pharmacology and Experimental Therapeutics)and other international organizations -- Ensures that learning follows professional industry standards.

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Pharmacology: PreTest Self-Assessment and Review

2009-08-25T04:28:00.000-07:00

Pharmacology: PreTest Self-Assessment and Review (Pretest Series)
Publisher:McGraw-Hill Medical Pages:430 2007-03-23 ISBN:0071471812 PDF 1.4 MB

This one-of-a-kind test prep guide helps you to get to know material on the pharmacology shelf exam and the USMLE Step 1; practice with 500 USMLE Step 1-style questions with referenced answers; review explanations for right and wrong answers; and build confidence, skills, and knowledge.

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Further MCQs in Pharmacy Practice

2009-08-25T04:27:00.002-07:00

Further MCQs in Pharmacy Practice
388 pages Pharmaceutical Press; 1 edition (September 7, 2006) ISBN: 0853696659 PDF 580 kb

This title offers multiple choice questions in pharmacy; a second of "MCQs in Pharmacy Practice". Papers including MCQs are a key component of undergraduate and postgraduate pharmacy exams. There are many MCQ publications in medicine but fewer in pharmacy despite the fact that pharmacy students encounter many MCQ exams during training. This book will be excellent preparation for these exams and can also be used for self-study.

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Drugs and Controlled Substances Information for Students

2009-08-25T04:27:00.001-07:00

Drugs and Controlled Substances: Information for Students is a medical reference product designed to inform and educate readers about a wide variety of drugs and controlled substances. The Gale Group believes the product to be comprehensive, but not necessarily definitive. It is intended to supplement, not replace, consultation with a physician or other health care practitioner. While the Gale Group has made substantial efforts to provide information that is accurate, comprehensive, and up-to-date, the Gale Group makes no representations or warranties of any kind, including without limitation, warranties of merchantability or fitnessfor a particular purpose, nor does it guarantee the accuracy, comprehensiveness, or timeliness of the information contained in this product. Readers should be aware that the universe of medical knowledge is constantly growing and changing, and that differences of medical opinion exist among authorities. Readers are also advised to seek professional diagnosis and treatment of any possible substance abuse problem, and to discuss information obtained from this book with their health care provider.

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MCQs in Clinical Pharmacy

2009-08-25T04:26:00.001-07:00

MCQs in Clinical Pharmacy
By Lilian M. Azzopardi

Publisher: Pharmaceutical Press

Number Of Pages: 276
Publication Date: 2007-05-30
ISBN-10 / ASIN: 0853696667
ISBN-13 / EAN: 9780853696667
Binding: Paperback

This is an invaluable revision aid for those preparing for multiple choice questions in clinical pharmacy. Questions in this textbook are practice-oriented and are intended to assess students' knowledge of clinical issues, evaluative and analytical skills, and ability to apply their knowledge in clinical practice. The MCQs will be presented as four practice tests and each test should take c3 hours. Each test will consist of 80 MCQs presented in a variety of formats. Main topics include: therapeutics and rational drug use; aetiology of disease states; presentation of conditions; investigations and diagnostic testing; drug therapy including adverse drug reactions; drug interactions; and contra-indications.

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Appleton and Lange's Review of Pharmacy

2009-08-25T04:25:00.001-07:00

Details
pages: 384 pages
Publisher: Appleton & Lange
ISBN: 0071360883
Format: PDF
Size: 83.9MB
Credit: faris

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Pharmaceutical Compounding and Dispensing

2009-08-25T04:24:00.001-07:00

This is a revision guide for students giving bullet points of basic information on pharmaceutical compounding and dispensing followed by questions and answers."Fast Track" is a new series of indispensable revision guides created especially for undergraduate pharmacy students.The content of each title focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs, case studies, sample essay questions and worked examples."The Fast Track" series provides the ultimate lecture notes and is a must-have for all pharmacy undergraduate students wanting to revise and test themselves for forthcoming exams.Based on the successful textbook, "Pharmaceutical Compounding and Dispensing", this book has been designed to assist the student compounder in understanding the key dosage forms encountered within extemporaneous dispensing.A Fast Track website will also be live at time of publication and will include MCQs, sample online content and much more.

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1-The Forensic Aspects of Poisons (Inside Forensic Science)

2009-08-25T04:22:00.000-07:00

By Richard Stripp"The Forensic Aspects of Poisons (Inside Forensic Science)"
Chelsea House Publications Pages: 128 2007-02-28 ISBN: 079109197X 2 MB

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2-Forensic Anthropology (Inside Forensic Science)

2009-08-25T04:21:00.002-07:00

By Bradley Adams"Forensic Anthropology (Inside Forensic Science)"
Chelsea House Publications Pages: 128 2006-09-30 ISBN: 0791091988 2 MB

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3-Forensic Medicine (Inside Forensic Science)

2009-08-25T04:21:00.001-07:00

By Howard C., M.D. Adelman"Forensic Medicine (Inside Forensic Science)"
Chelsea House Publications Pages: 104 2006-12 ISBN: 0791089266 7 MB

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4-Forensic DNA Analysis (Inside Forensic Science)

2009-08-25T04:20:00.000-07:00

By Louis Levine, Henrietta Margolis-nunno, Lawrence Kobilinsky"Forensic DNA Analysis (Inside Forensic Science)"
Chelsea House Publications Pages: 128 2007-02-28 ISBN: 0791089231 12 MB

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5-Forensic Pharmacology (Inside Forensic Science)

2009-08-25T04:19:00.000-07:00

By Beth E. Zedeck, Morris S. Zedeck"Forensic Pharmacology (Inside Forensic Science)"
Chelsea House Publications Pages: 128 2006-12 ISBN: 0791089207 1 MB

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6-Legal Aspects of Forensics (Inside Forensic Science)

2009-08-25T04:17:00.000-07:00

By Danielle S. Sapse"Legal Aspects of Forensics (Inside Forensic Science)"
Chelsea House Publications Pages: 114 2006-09-30 ISBN: 0791089258 1 MB

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Postmortem Toxicology of Abused Drugs

2009-08-25T04:16:00.000-07:00

MD, FFFLM, Steven B. Karch , "Postmortem Toxicology of Abused Drugs"
CRC; 1 edition (October 9, 2007) | ISBN: 1420054511 | 216 pages | PDF | 2,1 Mb

Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price.

Postmortem Toxicology of Abused Drugs considers the role of toxicology in the investigation of homicide, suicide, accident, natural death, and overdose. It gives practical insights and case reviews on conducting toxicology tests and completing toxicology reports. It explains chain of custody; specimen collection and security; sampling of blood, urine, bile, and vitreous humor; and the selection of post-mortem specimens. Analyzing various testing procedures, the book covers simple chemical tests, microdiffusion tests, chromatography, spectroscopy, and more. It also discusses methods and strategies for analysis; and covers quality assurance protocols and controls. To help avoid common pitfalls, the text demonstrates the proper interpretation of postmortem drug levels based on knowledge of pharmacokinetics, metabolism, and pharmacogenetics; post-mortem redistribution and diffusion; and other considerations such as synergistic toxicity, and drug instability. Heavily referenced and containing several tables, figures, and useful appendices, this book is a handy reference for forensic scientists and medical examiners involved with death investigation.

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Rang & Dale's Pharmacology, 6/e 2007

2009-08-16T21:50:00.002-07:00

By Humphrey P. Rang, Maureen M. Dale, James M. Ritter, Rod Flower

Publisher: Churchill Livingstone

Number Of Pages: 844

Publication Date: 2007-01-25

A straightforward way to master a complex subject! This bestselling textbook presents all the knowledge you need to get through your pharmacology course and beyondusing a clear and accessible approach that makes the material easy and interesting to learn. Progressing logically from a molecular understanding of receptors and drug actions to the clinical uses of the most important groups of drugsCox 2 inhibitors, pharmacogenetics, biopharmaceuticals, and drug abuseas well as "lifestyle drugs" such as performance-enhancing substances, botulinum toxin, and Viagra®. And now, online access via STUDENT CONSULT makes it an even more effective learning resource!, it delivers the latest information on cannabinoids and rimonabant,

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Lippincott's Illustrated Reviews: Pharmacology, 4th Edition

2009-08-16T21:50:00.001-07:00

Lippincott's Illustrated Reviews: Pharmacology, 4th Edition
(Lippincott's Illustrated Reviews Series)
By Richard A Harvey, Pamela C Champe, Richard Finkel, Luigi Cubeddu, Michelle A Clarke

Publisher: Lippincott Williams & Wilkins
Number Of Pages: 560
Publication Date: 2008-07-01
ISBN-10 / ASIN: 0781771552
ISBN-13 / EAN: 9780781771559
Binding: Paperback

Lippincott's Illustrated Reviews: Pharmacology, Fourth Edition enables rapid review and assimilation of large amounts of complex information about the essentials of medical pharmacology. Clear, sequential pictures of mechanisms of action actually show students how drugs work, instead of just telling them. As in previous editions, the book features an outline format, over 500 full-color illustrations, cross-references to other volumes in the series, and over 125 review questions. has been thoroughly updated, and a new chapter covers toxicology. New to this edition will be a companion Website containing all of the illustrations, fully searchable text, and an interactive question bank. NOTE: International Edition available for sales outside North America and Caribbean (ISBN: 978-1-60547-200-3)

FORM: HTML Pages

Concise Dictionary of Pharmacological Agents: Properties and Synonyms

2009-08-16T21:48:00.000-07:00

Publisher: Springer
Number Of Pages: 342
Publication Date: 1999-11-15
Sales Rank: 3857818
ISBN / ASIN: 0751404993
EAN: 9780751404999
Binding: Hardcover
Manufacturer: Springer
Studio: Springer
Average Rating:
Total Reviews:

This dictionary provides a convenient personal reference source, intended to complement more encyclopaedic works. First, there is an alphabetic, fully cross-indexed listing of pharmacologically active agents and their properties, containing details of some 4000 individual chemical agents including medical drugs in current use, experimental agents and toxins used as investigation tools. Over 10,000 alternative names are indexed, including chemical names, abbreviated chemical names, official pharmacological names, proprietary names and research code numbers. A key feature is that the properties of the agents are categorised, according to mechanism and use, into 300 classes -for each of which there are descriptive articles for which key literature and review references are provided.
Second, there is an alphabetical glossary explaining the meaning of some 3000 biomedical terms from pharmacology, biochemistry, molecular biology, immunology, pathology, physiology, anatomy and microbiology. Emphasis in explanation is given to terms that can cause confusion, for example those relating to drug receptors and to endogenous mediators.
Audience: This work provides indispensable information for researchers in the fields of pharmacology, medicinal chemistry and pharmaceutics, and biochemistry, as well as for medical and science writers and editors and drug regulatory officers.

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Treatments from Toxins - The Therapeutic Potential of Clostridial Neurotoxins

2009-08-16T17:31:00.001-07:00

Treatments from Toxins - The Therapeutic Potential of Clostridial Neurotoxins
CRC PRESS, 2007 ISBN: 9780849327094 K. Foster English 318p. 5.5 MB

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Fundamental Toxicology

2009-08-16T17:30:00.002-07:00

Fundamental Toxicology
Publisher: Royal Society of Chemistry 2006-03-27 ISBN: 0854046143 Pages: 462 PDF 3.4 MB

Product Description:
A-Z of Emergency Radiology is aimed at trainee and practising radiologists, as well as all other healthcare professionals involved in interpreting scans of all imaging modalities in the emergency room setting. It provides a simple, easily accessible guide to the key aspects of the most commonly encountered problems. The simple A-Z format of the book allows the reader to look up the key features of a known condition, or to quickly confirm a suspected diagnosis.

http://rapidshare.com/files/180084006/toxico.zip

Molecular and Biochemical Toxicology, 4th edition

2009-08-16T17:30:00.001-07:00

Robert C. Smart, Ernest Hodgson "Molecular and Biochemical Toxicology, 4th edition"
Wiley 2008-08-18 ISBN: 047010211X 902 pages PDF 8,7 MB

An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals

Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition.

Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include:

New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics
Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters
Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity
Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects.

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Principles of Biochemical Toxicology, Fourth Edition

2009-08-16T17:28:00.002-07:00

John A. Timbrell, "Principles of Biochemical Toxicology, Fourth Edition"
Informa HealthCare | 2008-11-18 | ISBN: 0849373026 | 520 p | PDF | 8 Mb

This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards. Principles of Biochemical Toxicology, Fourth Edition thoroughly explains dose-response relationships, disposition and metabolism, and toxic responses to foreign compounds, and presents detailed examples to make the mechanisms of toxicity more accessible to students encountering the subject for the first time. Comprehensive in scope with a clear and concise approach, the text includes summary sections, questions and model answers, and thoroughly revised artwork that serves as an essential aid to learning and teaching. New to the Fourth Edition:
reorganized sections that cover basic principles followed by sections on different types of toxicity extensive use of examples throughout and numerous explanatory diagrams new material on risk assessment, export systems, oxidative stress, Thalidomide, Tamoxifen and asbestos proliferators, domoic acid, bone marrow (benzene), heart (adriamycin), blood (primaquine), biomarkers, cytochrome P450 and other enzymes, receptor mediated effects, endocrine disruption, ethanol, botox, arsenic, and more questions with answers for each chapter for review and self-checking expanded and updated chapter bibliographiesd

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Microbial Food Contamination

2009-08-16T17:28:00.001-07:00

Microbial Food Contamination by Ph.D., Charles L. Wilson
CRC | 2007-10-08 | ISBN:0849390761 | 632 p | PDF | 3 M

Book Description:

Microbial Food Contamination, Second Edition is a comprehensive evaluation of the microbiology, biochemistry, detection, risk, and threat of foodborne illness in today's global climate. It introduces new insights into the pathogenic effect of contaminants including mycotoxins and aflatoxins. It presents recent advances in detecting and monitoring food borne human pathogens, and examines control and prevention measures including the genetic and biochemical control of aflatoxigenic fungi. Contributions discuss globalization and the increased risk for transnational contamination, the impact of food contamination on international trade, and international programs to mitigate these events. Finally, the book explores the risk of bioterrorism and considers a Food Defense Plan that can reduce vulnerability.

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Poisoning & Drug Overdose

2009-08-16T17:27:00.003-07:00

http://rapidshare.com/files/116436754/0071443339.pdf__5e3144e__via_gigapedia.info__.html

Preface Poisoning & Drug Overdose provides practical advice for the diagnosis and management of poisoning and drug overdose and concise information about common industrial chemicals.The manual is divided into four sections and an index, each identified by a black tab in the right margin. Section I leads the reader through initial emergency management, including treatment of coma, hypotension, and other common complications; physical and laboratory diagnosis; and methods of decontamination and enhanced elimination of poisons. Section II provides detailed information for approximately 150 common drugs and poisons. Section III describes the use and side effects of approximately 60 antidotes and therapeutic drugs. Section IV describes the medical management of chemical spills and occupational chemical exposures and includes a table of over 500 chemicals. The Index is comprehensive and extensively cross-referenced.The manual is designed to allow the reader to move quickly from section to section, obtaining the needed information from each. For example, in managing a patient with isoniazid intoxication, the reader will find specific information about isoniazid toxicity in Section II, practical advice for gut decontamination and management of complications such as seizures in Section I, and detailed information about dosing and side effects for the antidote pyridoxine in Section III.We are also grateful for the numerous comments and suggestions received from colleagues, students, and the editorial staff at McGraw-Hill, which helped us to improve the manual with each edition.Kent R. Olson, MD, FACEP, FACMT, FAACTSan Francisco, CaliforniaJuly 2006

Casarett & Doull's Essentials of Toxicology

2009-08-16T17:27:00.001-07:00

Casarett & Doull's Essentials of Toxicology (Repost)
McGraw-Hill Professional; 1 edition ISBN: 0071389148 512 pages CHM 8 Mb

Based on the “gold standard” text, this concise and accessible book distills the essentials of toxicology for pharmacy and medical students who want the best reference at their fingertips. The text features over 200 illustrations, summary tables, sections on “hot” research topics, and self-assessment questions and annotated answers for review.

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Casarett & Doull's Toxicology: The Basic Science of Poisons

2009-08-16T17:26:00.001-07:00

Curtis D. Klaassen “Casarett & Doull's Toxicology: The Basic Science of Poisons"
McGraw-Hill Professional 2007-11-20 ISBN: 0071470514 1280 pages PDF 27,5 Mb

Long established as the gold standard in the field, Casarett & Doull's Toxicology equips you with an unsurpassed understanding of modern toxicology, including the principles, concepts, mechanisms, and modes of thought that are the foundation of the discipline. The new edition features many new contributors, new content on chemical terrorism, and is updated throughout.

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Alcohol in Health and Disease

2009-08-16T17:25:00.002-07:00

Alcohol in Health and Disease
Informa Healthcare 2001-05-15 ISBN: 0824705335 632 pages PDF 4,1 Mb

This volume, based on presentations from the symposium on the health effects of alcohol held in Titisee, Germany, examines the physical and psychological consequences of alcohol use and abuse, and considers environmental and ethnic factors that lead to addiction and dependence. Discusses epidemiological studies that show the influence of light to moderate intake of alcoholic beverages on coronary heart disease! Featuring contributions from nearly 60 internationally recognized and respected authors, and over 2900 references for further investigation of the subject, Alcohol in Health and Disease · analyzes biochemical, pharmacogenetic, and pathologic disturbances that follow acute and chronic ingestion of alcohol · describes complications that arise from social, biological, and environmental factors · examines alcohol metabolic genes and their role in alcohol sensitivity, drinking habits, and dependence · spotlights hepatic and nutritional disorders associated with alcoholism · considers the relationship of alcohol to cancer · debates the French paradox · and more! Covering a multitude of disciplines, including molecular biochemistry, genetics, epidemiology, pathophysiology, neurobiology, and cardiology, Alcohol in Health and Disease is a critical reference for addiction psychiatrists, neuropsychopharmacologists, psychologists, geneticists, toxicologists, biochemists, environmental and public health scientists, health policy makers, social workers, counselors, and graduate and medical school students in these disciplines.

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Molecules of Death

2009-08-16T17:25:00.001-07:00

R. H. Waring, G. B. Steventon, S. C. Mitchell “Molecules of Death"
Imperial College Press 2007-08-06 ISBN: 1860948146 456 pages PDF 15 Mb

This book has been developed over many years from several popular courses taught to students at both Birmingham and London universities. It provides an important step in introducing principles and concepts within the field of toxicology. The underlying mechanisms of toxicity are highlighted through examples taken from gases, minerals, plants, fungi, bacteria, marine creatures, industrial chemicals and pharmacological agents. In this second edition, the text has been completely revised and expanded with the addition of six new chapters carbon monoxide, hydrofluoric acid, lead, mushroom, toxins, paracetamol, paraquat and diquat. Each chapter is self-sufficient, enabling readers to dip into chapters of interest at random without any lack of understanding. The book is informative, with numerous clinical details, and will appeal to those who wish to delve into this fascinating subject.

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Advances in Molecular Toxicology, Volume 1, 2

2009-08-16T17:24:00.000-07:00

Advances in Molecular Toxicology, Volume 1
Stationary Office Pages: 200 2006-12-09 ISBN: 0444528423 2 MB

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field.

Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed.

* Cutting edge reviews by leading workers in the discipline.
* In depth dissection of molecular aspects of interest to a broad range of scientists, physisicans and any student in the allied disciplines.
* Leading edge applications of technological innovations in the chemistry, biochemistry and molecular medicine.

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Nutritional Toxicology (Target Organ Toxicology Series)

2009-08-16T17:23:00.002-07:00

Nutritional Toxicology (Target Organ Toxicology Series)

Paperback: 472 pagesData: November 22, 2001Format: PDF

Description:

Nutrients are gaining recognition for their role in protecting against the toxic effects of free radicals, alcohol and other substances. At the same time, advances in food technology, the appearance of novel foods and new ingredients have generated new toxicological issues and forced health and safety professionals to develop new and more reliable methods to assess their impact on our health. These issues are at the heart of the second edition of Nutritional Toxicology. The book discusses the role of nutrients in protecting the body against toxicants. It explores the overall importance of the metabolism of xenobiotics and antioxidant nutrients in their increasingly important role in protecting against oxidative damage generated by free radicals. The book also discusses components of the diet that can influence metabolism of drugs, how alcohol consumption affects nutritional status, and conversely, how nutritional status affects alcohol metabolism. The effect of age on the body's ability to metabolize drugs and toxicants is discussed in detail.

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Toxicogenomics: A Powerful Tool for Toxicity Assessment (2008)

2009-08-16T17:23:00.001-07:00

Toxicogenomics: A Powerful Tool for Toxicity AssessmentPublisher: Wiley Language: English ISBN:0470518235 396 pages Data: 2008 PDF 6 Mb

Description:

Toxicogenomics: A Powerful Tool For Toxicity Testing provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology.

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The Herbal Pharmacy

2009-08-16T17:20:00.001-07:00

The Herbal Pharmacy 27.83 MB

For anyone looking to enhance their health, herbs are definitely worth looking into. Over thousands of years herbs have been used as important drugs and as simple medicinal remedies. Modern research has analyzed the plants and established sound scientific basis of much herbal medicine.

Contents The Herbal Pharmacy has collected about 300 of the most widely used herbs and listed their medical applications, along with:

Their common and alternate name
The family each herb belongs to
Parts of the herb used
Their properties
Internal applications, topical uses and topical applications
Culinary uses
Energetics (bitter, cool, dry)
Chemical constituents
Contraindications
Comments How Easy Is The Herbal Pharmacy To Install

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CRC Handbook of Medicinal Spices

2009-08-16T17:19:00.002-07:00

b]James A. Duke, Mary Jo Bogenschutz-Godwin "CRC Handbook of Medicinal Spices"[/b]
CRC ISBN 0849312795 2002-09-27 360 Pages PDF 3.6 Mb

"Let food be your medicine, medicine your food." -Hippocrates, 2400 B.C. When the "Father of Medicine" uttered those famous words, spices were as important for medicine, embalming, preserving food, and masking bad odors as they were for more mundane culinary matters. Author James A. Duke predicts that spices such as capsicum, cinnamon, garlic, ginger, onion, and turmeric will assume relatively more medicinal importance again, as the economic costs and knowledge of the side-effects of prescription pharmaceuticals increase. After all, each spice contains thousands of useful phytochemicals. Pharmaceuticals usually contain only one or two. Discover the Science behind the Folklore Spices are important medicines that have withstood the empirical tests of millennia. Nearly 5,000 years ago Charak, the father of Ayurvedic medicine, claimed that garlic lightens the blood, reduces tumors, and is an aphrodisiac tonic. Today scientists say it thins the blood, prevents cancer, and increases libido. For centuries people worldwide have used spices to cure a myriad of ailments and to preserve foods. Now science is proving that these spices may preserve us with their antioxidant and antiseptic activities. Organized by scientific name, the CRC Handbook of Medicinal Spices provides the science behind the folklore of over 60 popular spices. For each spice, it lists: Scientific name Common name Medicinal activities and indications Multiple activities Other uses, especially culinary Cultivation Chemistry Important phytochemical constituents and their activities The handbook also includes market and import data, culinary uses, ecology and cultural information, and discusses at length the use of spices as antiseptics and antioxidants.

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Protective Effects of Tea on Human Health

2009-08-16T17:19:00.001-07:00

N. K. Jain, M. Siddiqi, J. Weisburger "Protective Effects of Tea on Human Health"
CABI | 2007-06-14 | ISBN: 1845931122 | 288 pages | PDF | 1,6 MB

Bringing together the latest research from leading experts, this book provides an indispensable reference on the health benefits of drinking tea. It examines the general health giving properties of tea before moving on to a detailed review of the evidence for the beneficial effects of tea on specific ailments including cancer, the common cold, renal disease, cardiovascular disease, antiviral influenza, arthritis, lung and pulmonary ailments, aging, oral health, and dementia. The book concludes by challenging misconceptions of the effects of tea.

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Tree Nuts: Composition, Phytochemicals, and Health Effects

2009-08-16T17:18:00.001-07:00

Tree Nuts: Composition, Phytochemicals, and Health Effects (Nutraceutical Science and Technology)
by Cesarettin Alasalvar, Fereidoon Shahidi
Publisher: CRC 2008-12 352 Pages ISBN: 0849337356 PDF 2.8 MB

Nuts have been long perceived as a high-fat, high-calorie food, best avoided or consumed in moderation. However, research is showing that tree nuts are cholesterol-free and contain unsaturated fats which can help lower the risk of heart disease. Nuts also provide essential nutrients such as magnesium, chromium, zinc, and manganese. Like all plant foods they are high in fiber and phytochemicals. This book examines ten popular tree nuts and describes each nut's compositional characteristics, lipid characteristics, effects of consumption on serum lipid profiles, as well as their phytochemicals and role disease prevention. In addition the book covers allergens and uses for non-edible parts.

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The Canadian Encyclopedia of Natural Medicine

2009-08-16T17:07:00.000-07:00

The Canadian Encyclopedia of Natural Medicine Canadian Encyclopedia of Natural Cures
John Wiley & Sons Inc 400 pages 2009-02-28 ISBN: 0470839082 PDF 1.5mb

Healthconsciousness is an area of transformational and unprecedented growth in the North American public today. More and more people are seeking alternative solutions to conventional medical practices. For many, a natural approach to healing everything from common ailments to serious diseases is preferable when compared to the invasive medical procedures and prescription drugs that abound.
Sherry Torkos, one of Canada’s leading pharmacists is widely regarded for her knowledge of complementary medicine. Her latest book, The Canadian Encyclopedia of Natural Cures, is the definitive source for alternative health care for Canadians; it is totally comprehensive and easy-tofollow, providing natural cures for everyday problems such as insect bites and muscle aches, as well as for serious chronic disorders such as osteoporosis, Parkinson’s disease, and diabetes. Torkos emphasizes the role of lifestyle, nutrition, exercise and supplements in optimizing health and preventing disease. This book features a detailed A to Z reference of ailments and disease, with the latest information on the natural cures that have been proven to assist in their treatment. Detailed information will also advise readers of potential drug interactions that can occur when supplements are taken alongside prescribed medications.

Canadians seeking to create a more holistic and personalized health program for themselves and for their families will turn to this reference time and time again.

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Natural Remedies: Their Origins and Uses

2009-08-16T17:06:00.002-07:00

Finn Sandberg and Desmond Corrigan "Natural Remedies: Their Origins and Uses"
Published by CRC Press October 2001 ISBN : 0415272017 PDF Format, 178 pages English 6.5 MB

The past two decades have witnessed a phenomenal explosion of interest in the potential uses of plant medicines in healthcare and this has evoked the rebirth of pharmacognosy.
This volume is unique in that it is the first, in English, to employ the Anatomical, Therapeutic and Chemical (ATC) classification system, developed by the World Health Organization, to present information on the therapeutic uses of plants.
Initially developed in the Swedish edition 'Phytopharmaca Therapy', this volume expands the original concept and highlights the aspects of medicinal plants that are crucial for a comprehensive understanding of the role plant drugs can play in healthcare.

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70 Essential Chinese Herbal Formulas

2009-08-16T17:06:00.001-07:00

Bob Flaws “70 Essential Chinese Herbal Formulas"
Blue Poppy Press 1994-10-01 ISBN: 0936185597 250 pages Html 2,3 MB

At TCM colleges in China, undergraduates learn a basic repertoire of between 50 and 100 herbal formulas. This includes one or two formulas from each of 21 major categories. By learning to modify this core group of formulas with additions and subtractions, one will have a basic repertoire of formulas for most clinical occasions. This book is not meant to replace or compete with Bensky & Barolet's Chinese Herbal Medicine: Formulas & Strategies. It is meant as an outline for prioritized study and use by under-graduates and new practitioners

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Herbal Medicine, Healing & Cancer

2009-08-16T17:05:00.001-07:00

Donald Yance, Arlene Valentine “Herbal Medicine, Healing & Cancer"
McGraw-Hill 1999-09-11 ISBN: 0879839686 480 pages Html 1,3 MB

More and more people who have been diagnosed with cancer or related illnesses embrace alternative medicines, and seek out holistic practitioners who use vitamins, herbs, nutrition, homeopathy, and acupuncture to treat the disease. This long-awaited book by Donald Yance--one of the nation's most respected herbalists--is a major contribution to the literature of natural healing and cancer.

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Herbs for a Good Night's Sleep: Herbal Approaches to Relieving Insomnia Safely and Effectively

2009-08-16T17:04:00.002-07:00

David Hoffmann “Herbs for a Good Night's Sleep: Herbal Approaches to Relieving Insomnia Safely and Effectively"
Keats Pub 1997-10 ISBN: 0879837934 88 pages Html 1,1 MB

This detailed guide explores the different medicinal herbs that can help improve the depth and ease of sleep.

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Cannabis: The Genus Cannabis (Medicinal & Aromatic Plants)

2009-08-16T17:04:00.001-07:00

Cannabis: The Genus Cannabis (Medicinal & Aromatic Plants)
CRC ISBN9057022915 1998-11-19 PDF 286pages 2.65 Mb

Cannabis sativa has provided man with a source of fuel, textiles, paper, rope, medicines and intoxication for over 5000 years. This book contains a series of expert dissertations, supported by over 700 references on the history, ethnobotany, chemistry and analysis, and cultivation and processing of cannabis. The medicinal and non-medicinal uses of the plant and its derivatives are viewed in the context of national and international legislation to define and control its use. Developments in cannabinoid pharmacology research and receptor theory are also discussed.
This book provides a comprehensive overview of cannabis use and abuse and will be an invaluable reference source for anyone with an interest in the wide range of applications of this fascinating plant and its therapeutic and commercial potential.

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Herbal Supplements-Drug Interactions: Scientific and Regulatory Perspectives

2009-08-16T17:03:00.002-07:00

The international popularity of herbal remedies has recently outpaced quality information on the utilization and dosing of these compounds. This book fills a void in the literature by offering an authoritative overview of the mechanisms of herbal remedies and their impact on standard medications. It offers a practical approach that focuses not only on specific drug interactions, but the mechanisms behind those interactions and their clinical significance. With contributions from leading experts on the subject, this text examines the overall use of herbs, includes sections on individual herbs, and considers pertinent regulatory issues and concerns in industry.

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Materia medica software

2009-08-16T17:03:00.001-07:00

User friendly revolutionary program that will allow you quickly and easily improve the accuracy of your clinical observations, diag- nosis and herbal prescriptions.

With a few clicks of the mouse, you can quickly and easily see more clearly the possibilities and best use of interconnected formulas, conditions, and actions.

Over 140 herbs and over 400 specific ailments are referenced
Search by indication
Unique search by multiple actions
The program offers you the ability to add your own data.
Preparation methods are given for each herb
Adult dosage ranges for all appropriate preparations are given

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Herbal Medicine: A Guide for Health Care Profesionals

2009-08-16T17:02:00.001-07:00

Herbal Medicine: A Guide for Health Care Profesionals .
Pharmaceutical Press ISBN: 0853694745 2002-06-15 (2nd edition) html 296 pages 1.4 Mb RS

A general disillusionment with conventional medicines, coupled with the desire for a "natural" life style has resulted in an increasing utilization of complementary and alternative medicine (CAM) across the developed world. The global market for herbal products has grown rapidly in the past decade, yet the majority are not assessed for their quality, safety and efficacy. This completely revised and updated edition of Herbal Medicines aims to answer the questions raised for the healthcare professional by providing scientifically rigorous, impartial information on medicinal herbs. It contains: informs on quality, safety and efficacy; offersan overview of UK and European leglisation concerning herbal products; offers an account and examples ofthe scientific methods for investigating the chemical constituents of herbs and for determining their biological activities; deals with 148 herbs commonly present in herbal remedies sold by pharmacies in the UK; enables the healthcare professional to advise the public on the rational and safe use of medicines; and presents various appendices grouping together herbs with specific actions highlighting potential interactions with conventional medicine.

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An Introduction to Complementary Medicine

2009-08-16T17:01:00.000-07:00

Terry Robson, "An Introduction to Complementary Medicine"
Allen & Unwin Academic 2004-09-01 ISBN: 1741140544 384 pages PDF 1,6 MB

Providing a sound introduction to the range of treatments and philosophies within the field of complementary and alternative medicine, this book offers a systematic explanation of the philosophies and practices that underpin these medical practices. The rise in popularity of complementary medicine is examined along with challenges of developing a more integrated system of healthcare. Such questions as What is complementary medicine? What evidence is there to support its use? and What can orthodox medicine learn from holistic practice? are answered. Among topics discussed are herbal medicine, massage, aromatherapy, yoga, and ayurveda.

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Cancer Drug Design and Discovery

2009-08-13T06:33:00.000-07:00

Stephen Neidle "Cancer Drug Design and Discovery"

Academic Press 2007-10-15 ISBN: 0123694485 448 pages PDF 7 MB

The ultimate source of information on the design of new anticancer agents, emphasising small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumours. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry, and clinicians taking oncology options.

* Covers both currently available drugs as well as those under development
* Provides a clinical perspective on trials of new anticancer agents
* Presents drug discovery examples through the use of case histories

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Mechanisms of Disease: An Introduction to Clinical Science

2009-07-17T04:21:00.001-07:00

Stephen Tomlinson, "Mechanisms of Disease: An Introduction to Clinical Science"
Cambridge University Press 2008-04-21 0521818583 340 p PDF 13.4 Mb

To reflect the changing face of undergraduate and postgraduate medical education, this new edition emphasises the principles of disease processes and their underlying mechanisms, bringing the content up to date with the latest developments from the fields of molecular and cellular biology. The focus is on describing the fundamental features of pathophysiological processes with examples to illustrate the similar mechanisms underlying apparently diverse clinical conditions. By understanding the cellular interactions in one disease area, similar principles can be applied to other disease groups and to the scientific basis of medical management and treatment strategies. Throughout, the student is encouraged to evaluate and integrate the evidence critically, developing skills for self-directed learning and the application of knowledge. To further encourage the reader to integrate the theory with clinical practice, each chapter concludes with a series of clinical scenarios and MCQs, with answers provided.

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Encyclopedia of Mind Enhancing Foods, Drugs and Nutritional Substances

2009-07-17T04:20:00.000-07:00

David Group, "Encyclopedia of Mind Enhancing Foods, Drugs and Nutritional Substances"
McFarland & Company ISBN 0786408537 2000-12-15 221 Pages PDF 1 Mb

It seems as though every day brings a new pill or potion claiming to restore mental alertness or improve memory. While many of these claims are based on factual information, many others are not. This encyclopedia of foods and drugs that are believed to improve mental performance contains information on nearly 400 nutrients, herbs, and drugs, ranging from ancient plant compounds to the latest pharmaceuticals. Entries are arranged by type of substance, such as foods, vitamins, minerals, spices, and medical drugs. Each entry contains information such as alternate names and forms, sources, results, side effects, precautions, and recommended dosage. Although readers are encouraged to consult with their doctors before diagnosing and treating themselves, this book provides crucial, factual, and unbiased information on the "miracle drugs" that many people believe can solve health problems from fatigue to Alzheimer's. Readers can discover for themselves the properties of each substance. A complete index allows for easy reference and help with alternate names, food and drug interactions, and symptoms.

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Pharmaceutical Microbiology

2009-07-17T04:19:00.000-07:00

Pharmaceutical Microbiology
Summary:
A textbook for undergraduate pharmacy students and for microbiologists entering the pharmaceutical industry, introducing the aspects of general microbiology that impinge on that industry. Covers the biology of micro-organisms, antimicrobial agents, and microbial aspects of pharmaceutical processing. First published in 1977 and updated from the 1992 edition with new chapters on vaccination and immunization to act as a link to updated material on the principles of immunity and the production of immunological products. The chapter on antibiotic assays did not make the cut, because so few development have taken place in the field that the coverage in previous editions was deemed sufficient. Other chapters have been enlarged, streamlined, or rewritten by new authors to reflect current conditions.

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Prescription and Non-prescription Drugs

2009-07-17T04:18:00.002-07:00

Revised and updated, this classic bestseller provides the necessary information about all the prescription and nonprescription drugs that the public has come to rely on. With revised information on new FDA regulations, this reference covers 5,000 brand names and 700 generic names.

Product details

Author	Griffith, H. Winter
Publication Date	11/2006
Roles	Griffith, H. Winter : Author
Dewey	615.1
Format	Trade Paperback
MSRP	19.95
Pages	01090
Roles	Moore, Stephen W. : Revised by
Subject	Drug Guides
ISBN	0399532897
Subject	Reference

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Medicinal Chemistry of Bioactive Natural Products by Xiao-Tian Liang

2009-07-17T04:18:00.001-07:00

Medicinal Chemistry of Bioactive Natural Products by Xiao-Tian Liang (Editor), Wei-Shuo Fang (Editor)[REPOST]
Publisher: Wiley (March 10, 2006) ISBN: 0471660078 PDF 5,3 Mb 460 pages

Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies-developed for natural products-with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents.

Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research.

Enhanced by examples with updated research results, the discussion covers such topics as:
* The chemistry and biology of epothilones
* Vancomycin and other glycopeptide antibiotic derivates
* Antitumor and other related activities of Taxol and its analogs
* The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin)
* Huperzine A: A natural drug for the treatment of Alzheimer's disease
* The medicinal chemistry of ginkgolides from Ginkgo biloba
* Recent progress in Calophyllum coumarins as potent anti-HIV agents
* Plant-derived anti-HIV agents and analogs
* Chemical synthesis of annonaceous acetogenins and their structurally modified mimics

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Concepts In Clinical Pharmacokinetics

2009-07-17T04:15:00.002-07:00

Concepts In Clinical Pharmacokinetics
Publisher:American Society of Health-System Pharm Pages:230 2005-10-30 ISBN:1585281247 CHM 2.1 MB

Programmed manual presents basic pharmacokinetic concepts and procedures. Material relates to individualization of drug dose regimens. Topics include pharmacokinetics, half-life, elimination rate, AUC, two-compartment models, drug elimination process, vancomycin, and more. For pharmacists and practitioners. Softcover. DNLM: Pharmacokinetics-Programmed Instruction.

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Essentials of Pathophysiology for Pharmacy

2009-07-17T04:15:00.001-07:00

Essentials of Pathophysiology for Pharmacy
Publisher:CRC Pages:248 2002-08-28 ISBN:1587160366 PDF 3.4 MB

This textbook stresses topics in pathophysiology that are most pertinent to students pursuing degrees in pharmacy. It is designed to provide students with a clear rationale for the use of a specific drug in selected disease states. The text is also supplemented with "Key Term" boxes that provide clear definitions of medical and physiologic terms. Drug boxes throughout the text provide a concise synopsis of selected drugs associated with the particular disease state, including generic and class names, routes of administration, major side effects and contradictions. Numerous tables and charts are also offered to expand upon and summarize key elements as are questions, study objectives, and diagnostic tools boxes are included.

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Melmon and Morrelli's Clinical Pharmacology

2009-07-17T04:14:00.000-07:00

Melmon and Morrelli's Clinical Pharmacology
Publisher:McGraw-Hill Medical Pages:1433 2000-05-25 ISBN: 0071054065 CHM 14.6 MB

* Perfect for the student, primary care practitioner, and pharmacist who needs both basic and clinical information to apply therapeutics.
* A new overview chapter--plus practical steps required for optimal therapeutic decisions.
* Coverage of newly emerging advances in therapeutics.
* A new look at cost/benefit analysis of therapy.
* Increased emphasis on drug interactions, and much more.

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Comprehensive Pharmacy Review NAPLEX Preparation

2009-07-17T04:13:00.000-07:00

NAPLEX®
Fifth Edition
by Leon Shargel

Comprehensive Pharmacy Review contains over 1,000 NAPLEX®-format questions from the best-selling Comprehensive Pharmacy Review, Sixth Edition and Comprehensive Pharmacy Review Practice Exams, 5th Edition.

All questions in Comprehensive Pharmacy Review reflect the latest progress in pharmacy education and practice.

Contents

NAPLEX Blueprint

Part I: Pharmaceutical Sciences

Drug Product Development in the Pharmaceutical Industry
Pharmaceutical Calculations and Statistics
Pharmaceutical Principles and Drug Dosage Forms
Biopharmaceutics and Drug Delivery Systems
Extemporaneous Prescription Compounding
Basic Pharmacokinetics
Bioavailability and Bioequivalence
Functional Group Chemistry and Biochemistry
Microbiology
Immunology
Biotechnology Drug Products
Principles of Pharmacodynamics and Medicinal Chemistry
Medicinal Chemistry and Pharmacology: Drugs Affecting the Nervous System
Autocoids and Their Antagonists, Nonnarcotic Analgesic—Antipyretics, and Nonsteroidal Anti-Inflammatory Drugs
Medicinal Chemistry and Pharmacology: Cardiovascular and Diuretic Drugs
Medicinal Chemistry and Pharmacology: Endocrinology and Related Drugs
Drug Metabolism, Prodrugs and Pharmacogenetics
Drug-Drug and Drug-Nutrient Interactions
Nuclear Pharmacy

Part II: Pharmacy Practice

Pharmaceutical Care and Disease State Management
Drug Information Resources
Adverse Drug Reaction Reporting
Medication Errors
Clinical Toxicology
Federal Pharmacy Law
Reviewing and Dispensing Prescription and Medication Orders
Sterile Products
Parapharmaceuticals, Home Diagnostics, and Medical Devices
OTC Otic, Dental and Ophthalmic Agents
OTC Dermatological Agents
OTC Weight Control, Sleep Aids, and Smoking-Cessation Aids
OTC Agents for Fever, Pain, Cough, Cold and Allergic Rhinitis
OTC Agents for Constipation, Diarrhea, Hemorrhoids and Heartburn
OTC Menstrual, Vaginal and Contraceptive Agents
Herbal Medicines and Nutritional Supplements
Clinical Pharmacokinetics and Therapeutic Drug Monitoring
Drug Use in Special Patient Populations: Pediatric, Pregnant, and Geriatric
Clinical Laboratory Tests
Coronary Artery Disease
Cardiac Arrhythmias
Hypertension
Heart Failure
Thromboembolic Disease
Infectious Diseases
Seizure Disorders
Parkinson's Disease
Schizophrenia
Mood Disorders
Asthma and Chronic Obstructive Pulmonary Disease
Osteoarthritis and Rheumatoid Arthritis
Hyperuricemia and Gout
Peptic Ulcer Disease and Related Acid-Associated Disorders
Diseases of the Bowel: Inflammatory Bowel Disease and Irritable Bowel Syndrome
Diabetes Mellitus
Thyroid Disease
Renal Failure
Cancer Chemotherapy
Pain Management
Nutrition and the Hospitalized Patient
Immunosuppressive Agents in Organ Transplantation
Outcomes Research and Pharmacoeconomics

Appendices
Index

Size: 96 Mb

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Pharmacology for the Health Care Professions

2009-07-17T04:12:00.003-07:00

Pharmacology for the Health Care Professions
Publisher:Wiley Pages:376 2008-12-10 ISBN:0470510188 PDF 1.2 MB

Pharmacology for the Health Care Professions is an accessible introduction to the pharmacology necessary for health care professionals training to be non-medical prescribers looking for an overview of the subject. The book covers the pharmacology necessary for accredited training programmes in non-medical prescribing and certification in access and supply of prescription-only medicines and will be useful as an ongoing reference for future use in practice.

Opening with a general introduction to pharmacology as a science, the book goes on to explain what is meant by drugs and medicines and why pharmacology should be of relevance to health care professionals. The reader is presented with general principles of pharmacology followed by systemic pharmacology that covers the actions of important groups of drugs in common use to treat diseases and conditions of the cardiovascular, respiratory, endocrine, musculoskeletal, skin and central nervous systems. The physiology and pathophysiology relevant to the understanding of how these drugs work is included.

Finally the book explores the law in relation to the sale, supply, administration and prescription of drugs and explains what is meant by non-medical prescribing. All aspects of non-medical prescribing are considered including the use of exemptions to the Medicines Act, patient group directions, supplementary prescribing and the development of independent prescribing for nurses and pharmacists.

Pharmacology is explained in simple, easy to understand terms and the book avoids any unnecessary chemistry where possible. Case studies that are of particular relevance to health care professionals are used throughout to illustrate the importance of the pharmacology major body systems and pathologies and the potential problems of adverse drug reactions and drug-drug interactions.

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Pharmacoepidemiology

2009-07-17T04:12:00.001-07:00

The Third Edition of this successful book has been revised and updated to include the latest advances in the field. It incorporates new topics such as prescription event monitoring, general practice research database, and drug utilization review.

Provides an American and European perspective.
The authors are renowned in the field.

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Dictionary of Pharmacoepidemiology

2009-07-17T04:11:00.001-07:00

Written by an internationally renowned authority in the field, this is the most complete dictionary devoted specifically to the terms currently used in pharmacoepidemiology. The use of
clear and consistent terminology in science has never been more important, and this dictionary, which has been translated from the third edition of a French original, has been reworked to include suggestions made by pharmacoepidemiologists currently using existing versions. It contains revised definitions for nearly all established terms in addition to comprehensive descriptions of new terms and is well illustrated with practical examples. This outstandingly high-quality dictionary will be essential for all those whose work is within or touches upon this field: regulatory authorities, pharmaceutical physicians, lawyers, pharmacists, researchers, evaluators and students.

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Global Pharmaceutical Marketing: A Practical Guide to Codes and Compliance

2009-07-17T04:10:00.001-07:00

Worldwide, there are varying Codes of Practice/Conduct for the pharmaceutical industry that ensure the industry self-regulates to promote the appropriate use of medicines by operating in a professional, ethical and transparent manner and ensuring high standards.The aim of this book is to aid the understanding of the many pharmaceutical Codes of Practice/Conduct throughout the world. It contains an overview of the guidelines for the promotion of pharmaceutical products in all geographical areas.Each section includes a "general overview" providing a discussion on that particular Code of Practice and differences/similarities with other countries.

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AHFS Drug Information.....the 2008

2009-07-17T04:09:00.001-07:00

First published in 1959, the "Big Red Book," as it's come to be known, has gone the extra mile for pharmacists and healthcare professionals seeking answers to the most detailed questions. It provides more extensive evidence-based data than any other drug reference. AHFS DI is the only reference free from the influence of manufacturers, insurers, regulators, and other special interests, giving you an unbiased source of drug information.

if messages about scripts error bother you try this:first define the drug you want, than click on + to open all subfolder which lie in the medicine name direction, than click on + near folder Document Body Date - and choose AFHS Drug InformationB(2008) - if you will work in such way you will recieve only one message about error.

http://rapidshare.com/files/169063915/tahfs8t.zip

Pharmacotherapy in Primary Care

2009-07-17T04:08:00.001-07:00

William Linn, Marion Wofford, Mary Elizabeth O'Keefe, L. Michael Posey "Pharmacotherapy in Primary Care"
McGraw-Hill Medical 2008-09-21 ISBN: 0071456120 544 pages PDF 3,6 MB

A complete single-source guide to drug therapeutics for primary care
Pharmacotherapy in Primary Care gives you a uniquely balanced, all-inclusive look at drug therapies for all the conditions commonly seen in primary care and clinical pharmacy -- from cardiovascular to nutritional disorders.
The book's diverse authorship -- comprising both physicians and pharmacists -- ensures that content is delivered in the most complete, relevant, and impartial way possible. Ideal for use at the point of care, this handy resource is conveniently organized by disorder and utilizes a standard template for therapeutic decision-making.
FEATURES.
A high-yield, systematic review of the clinical literature that informs pharmacotherapy interventions.
Specific recommendations that optimize drug therapy for each disorder covered in the book.
Helpful treatment algorithms to speed clinical decision-making.
Evidence-based summaries that present the book's insights within the highly practical context of evidence-based medicine .
Important emphasis on identifying the variables that go into initial drug therapy decisions--plus key issues related to long-term monitoring, contingency planning, and referral

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Encyclopedia of Molecular Pharmacology

2009-07-17T04:07:00.001-07:00

A fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

http://rapidshare.com/files/177749248/tencyclo_molec_pharmaco2ed.zip

The Art of Drug Synthesis

2009-07-17T04:06:00.000-07:00

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis.

Edited by prominent scientists working in drug discovery for Pfizer
Meets the needs of a growing community of researchers in pharmaceutical R&D
Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students
An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

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Burger's Medicinal Chemistry and Drug Discovery, 6 Volume Set, 6th Edition

2009-07-17T04:05:00.000-07:00

Here >> Volumes from 1 to 5 only .. trying to find 6

This new sixth edition of Burger's Medicinal Chemistry and Drug Discovery offers several new and unique features. For the first time, an online version of this major reference work will offer updated content from the print edition and easy access. For the first time, all volumes are structured entirely according to content and published simultaneously to provide broad coverage of medicinal chemistry and drug discovery for new or experienced medicinal chemists, biologists, pharmacologists and molecular biologists. This includes a current and global perspective of drug design, and drug development.With expanded content from 69 chapters to over 100 chapters, this sixth edition of Burger's Medicinal Chemistry and Drug Discovery includes more than 50% new material. An entire section has been dedicated to cancer research. Areas included are those at the foreground of life science including:* Proteomics* Genomics* Bioinformatics* Combinatorial Chemistry* High-Throughput Screening* Blood Substitutes* Allosteric Effectors as Potential Drugs* COX Inhibitors* Statins* High-Throughput Pharmacology* and More.The new sixth edition of Burger's Medicinal Chemistry and Drug Discovery is a Memorial Edition to Professor Alfred Burger who published this major reference work in the first edition as "Medicinal Chemistry" in two volumes in 1951. Dr. Burger's research focused on analgesics, antidepressants and chemotherapeutic agents. He is one of the few academicians to have a drug, designed and synthesized in his laboratories and brought to market. Dr. Burger's contribution to the fields of medicinal chemistry and drug discovery are well renowned and documented. He received the Louis Pasteur Medal of the Pasteur Institute and the American Chemical Society Smissman Award.

Content

VOLUME 1
Structure Based Drug-Design
History of Quantitative Structure Activity Relationships
Recent and Developing Trends in QSAR: From Data Analysis and Model Validation to Drug Design and Discovery
Molecular Modeling in Drug Design
Drug-Target Binding Forces: Advances in Force Field Approaches
Combinatorial Library Design, Molecular Similarity and Diversity Applications
Virtual Screening
Docking and Scoring Functions/Virtual Screening
Bioinformatics
Chemical Information Computing Systems in Drug Discovery
X-ray Crystallography Drug Discovery
Electron Microscopy of Biological Macromolecules
Design of Peptidomimetics
Approaches to the Rational Design of Enzyme Inhibitors
Chirality and Biological Activity
Structural Concepts in the Prediction of the Toxicity of Therapeutical Agents
Natural Products as Leads for New Pharmaceuticals
Analog Design
NMR and Drug Discovery
Mass Spectrometry and Drug Design
VOLUME 2
Combinatorial Chemistry and Multiple Parallel Synthesis
Highthroughput Screening for Lead Discovery
High Throughput Pharmacology
The Application of Recombinant DNA Technology in Medicinal Chemistry and Drug Discovery
Oligonucleotide Therapeutics
Therapeutic Agents Acting on RNA
Carbohydrate Based Therapeutics
Membrane Transport Proteins and Drug Transport
Allosteric Proteins and Drug Discovery
Receptor Targets in Drug Discovery and Development
Large Scale Synthesis
Principles of Drug Metabolism
Metabolic Considerations in Prodrug Design
Retrometabolism-Based Drug Design and Targeting
Drug Discovery: The Role of Toxicology
Drug Absorption, Distribution, and Elimination
The FDA and Regulatory Issues
Intellectual Property in Drug Discovery and Biotechnology
Nicotinic Acetylcholine Receptors
Physicochemical Characterization and Principles of Oral Dosage Form Selection
VOLUME 3
Cardiac Drugs: Antianginal, Vosodilators, Antiarrhythmic
Diuretics and Uricosuric Agents
Myocardial Infarction Agents
Endogenous Vasoactive Peptides
Hematopoietic Agents
Anticoagulatns, Antithrombotics and Hemostatics
Antihyperlipedemic Agents
Oxygen Delivery via Allosteric Effectors of Hemoglobin, Blood Substitutes, and Plasma Expanders
Sickle Cell Anemia
Iron Chelators and Therapeutic Uses
Thyroid Hormones and Thyromimetics
Male Sex Hormones, Analogs, and Antogonists
Anti-inflammatory Steroids
Female Sex Hormones, Contraceptives & Fertility Drugs
Fundamentals of Steroid Chemistry and Biochemistry
VOLUME 4
Peptide and Protein Hormones, Peptide Neurotransmitters, and Therapeutic Agents
Inhibitors of Gastric Acid Secretion
Chemokines and Cytokine Modulators
COX Inhibitors and Leukotriene Modulators
Agents Acting on Prostanoid Receptors
Retinoids
Vitamins
Life Style and Over-the-Counter Agents
Radiopaques
Microarrays and Gene Expression Profiling Applied to Drug Research
SNPs: Single Nucleotide Polymorphisms and Pharmacogenomics
Gene Therapy with Plasmid DNA
Insulin and Hypoglycemic Agents
VOLUME 5
Molecular Biology of Cancer
Synthetic DNA-targeted Chemotherapeutic Agents and Related Tumor-Activated Prodrugs
Antitumor Natural Products
Radiosensitizers and Radioprotective Agents
Synthetic Anti-angiogenic Agents
Future Strategies in Immunotherapy
Selective Toxicities
Drug Resistance in Cancer Chemotherapy
Antiviral Agents, DNA
Antiviral Agents, RNA (Viruses other than HIV), Orthopoxviruses
Rationale of Design of Anti-HIV Drugs
Organ Transplantation Drugs
Synthetic Antibacterial Agents
Lactam Antibiotics
Tetracyclines, Aminolycoside, Macrolide, and Miscellaneous Antibiotics
Antimycobacterial Agents
Antifungal Agents
Antimalarial Agents
Antiprotozoal Agents
Anthelmintic Agents
VOLUME 6
Andrenergics and Andrenergic Blocking Agents
Cholinergics
Anticholinergic Drugs
CNS Stimulants
Sedatives and Hypnotics
Anticonvulsants
Analgesics
Antidepressants
Antianxiety Agents
Antipsychotic Agents
Investigative Agents for use in Neurodegenerative Conditions
Therapeutic and Diagnostic Agents for Parkinson's Disease
Alzheimer's Disease: Search for Therapeutics
Cognition Enhancers
Drugs to Treat Eating and Body Weight Disorders

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Vol 1 burgers medicinal chemistry.pdf
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Vol 2 burger textbook of medicinal chemistry.pdf
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Vol 3-burger medicinal chemistry.pdf
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Vol 4-burger medicinal chemistry.pdf
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Vol 5-burger medicinal chemistry.pdf
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Innovation in the Biopharmaceutical Industry

2009-07-17T04:03:00.000-07:00

Publisher: World Scientific Publishing Company
Number Of Pages: 150
Publication Date: 2007-05-29
ISBN-10 / ASIN: 9812706607
ISBN-13 / EAN: 9789812706607
Binding: Paperback

Product Description:

Innovation is at the heart of all advances and has the capacity to solve problems facing humanity. Societies which have turned away from innovation and technological development have failed in their ability to support their populations. Understanding the nature of innovation in the life sciences and in particular healthcare, how it operates, what enables and hinders it is therefore of great importance to meeting the challenges ahead. This book, originally and concurrently published in the International Journal of Innovation Management, Vol. 11, No. 2, 2007, offers the latest research and insights concerning innovation in the biopharmaceutical industry.

http://rapidshare.com/files/12 371040...L_INDUSTRY.pdf

Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet

2009-07-17T04:02:00.002-07:00

Alan Crozier "Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet"
Wiley-Blackwell 2006-12-11 ISBN: 1405125098 384 pages PDF 9 MB

Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet covers the main groups of natural products from a chemical and biosynthetic perspective with illustrations of how genetic engineering can be applied to manipulate levels of secondary metabolites of economic value as well as those of potential importance in diet and health. These descriptive chapters are augmented by chapters showing where these products are found in the diet, how they are metabolized and reviewing the evidence for their beneficial bioactivity.

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Textbook of Pharmacoepidemiology (2007)

2009-07-17T04:02:00.001-07:00

Textbook of Pharmacoepidemiology
Publisher: Wiley Language: English ISBN: 0470029250 518 pages Data: 2007 PDF 3 Mb

Description: The Textbook of Pharmacoepidemiology provides a streamlined text for evaluating the safety and effectiveness of medicines. It includes a brief introduction to pharmacoepidemiology as well as sections on data sources, methodology and applications. Each chapter includes key points, case studies and essential references.

* One-step resource to gain understanding of the subject of pharmacoepidemiology at an affordable price
* Gives a perspective on the subject from academia, pharmaceutical industry and regulatory agencies
* Designed for students with basic knowledge of epidemiology and public health
* Includes many case studies to illustrate pharmacoepidemiology in real clinical setting

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