The rapid progress in biology will continue to change the methodological approach to drug discovery in the coming years. Electronic media will continuously help researchers to access and share information. It is, however, becoming more and more evident that many young pharmacologists have only limited training in classical pharmacological methodologies. These long-standing and still highly relevant methods are simply not available in the electronic databases. Drug Discovery and Evaluation:Pharmacological Assays bridges this gap by comprehensively covering the pharmacological methods that have been utilized successfully for more than a hundred years as well as the latest technologies.

The classical methods and the newest technologies, all in one book!

The 3rd edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal, and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described.

For this third edition, all existing chapters have been revised and completely updated. A large number of assays were added: we are now publishing two volumes. Sections that have been specifically enlarged include - Pharmacological assays in thrombosis and haemostasis (formerly called activity of blood constituents), - Antidiabetic activity (includes completely new chapters such as Biochemical Methods in Diabetology), - Anti-atherosclerotic activity.

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Cocaine (Drugs: the Straight Facts) (US$30)
Stationary Office Pages: 112 2003-03 ISBN: 0791072606 10 MB
Cocaine is a very addictive drug. Cocaine is a stimulant it directly affects your brain. Cocaine stimulates certain nerve cells in the brain, producing feelings of intense pleasure. Users talk about feeling carefree, or relaxed, or utterly in control. But this artificial stimulation comes with a price tag. The “high” from cocaine lasts only from five to 20 minutes, and you will need more and more cocaine each time you try to match the feelings of that first, initial experience. Cocaine causes severe mood swings and irritability. As soon as cocaine enters your bloodstream it goes to work, increasing your heart rate and raising your blood pressure. It increases your body’s temperature and causes the pupils of your eyes to dilate. Repeated sniffing of cocaine powder causes your nose to become irritated and frequently runny. The cocaine can even eat away at the cartilage in your nose, producing holes.

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This revised edition assesses the range of non-prescription, over-the-counter medicines that can be recommended for the most frequently encountered minor illnesses. The first edition has been updated to reflect changes in the legal status and availability of products and new opinions on and approaches to treatment. A new section on emergency hormonal contraception is also included. The information is presented in a structured formulary format with products described both generically and by brand name along with supplier details. Each chapter also contains a summary of key points with suggestions regarding the most appropriate products. The book should enable pharmacists, GPs, nurses and other healthcare professionals to make well-informed recommendations and to give patients and customers sound advice on non-prescription medicines.

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