May 2011 Volume 43 Number 5, pp 389 - 499
Visit Nature Genetics online to browse the journal.
Now available at http://links.ealert.nature.
Please note that you need to be a subscriber to enjoy full text access
to Nature Genetics online. To purchase a subscription, please visit:
http://links.ealert.nature.
Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.
GENOMIC Know-How. Discovery is all about pushing the boundaries of
what's possible. That's why Expression Analysis harnesses hundreds
of years of collective experience into something we call Genomic
Know-How. For you this means access to experts. For your research,
it means the best chance to breakthrough. Experience it today.
919-405-2248 * 866-293-6094
http://links.ealert.nature.
http://links.ealert.nature.
See the Light. Make the Switch. Stop Cloning!
The LightSwitch Luciferase Assay System provides everything you need
for reporter assays: pre-cloned human promoters and 3'UTRs in
luciferase reporter vectors plus optimized luciferase reagents to
measure promoter induction and miRNA target validation.
Visit SwitchGear Genomics and explore our genome-wide collections
and validated pathway sets.
http://links.ealert.nature.
12th INTERNATIONAL CONGRESS OF HUMAN GENETICS
ASHG and the IFHGS invite you to the 12th International Congress
of Human Genetics (ICHG), on October 11-15, 2011, in Montreal,
Canada. Submit an abstract, apply for a travel grant, and register
to attend the largest human genetics meeting ever with more than
7,500 of your colleagues from around the world.
http://links.ealert.nature.
Nature Reviews Genetics
Focus on Gene-Based Therapies
http://links.ealert.nature.
This Focus issue brings you up to date with progress in gene-based
therapies, including gene delivery using viral vectors, strategies
based on RNA-mediated silencing, and approaches that use stem and
progenitor cells. All articles in the Focus are available for free
for one month.
EDITORIAL
----------------------
No second thoughts about data access p389
doi:10.1038/ng.827
More data than we can handle is no excuse to give up our efforts to
promote data access, but it may make us think about new ways to make it sustainable.
http://links.ealert.nature.
Variants modulating the expression of a chromosome domain encompassing PLAG1
influence bovine stature pp405 - 413
Latifa Karim et al.
doi:10.1038/ng.814
Michel Georges and colleagues report fine mapping and functional characterization
of a quantitative trait locus with a large effect on bovine stature. They show
that the likely causal variants at this locus modulate expression of a
chromosomal domain encompassing PLAG1 and several other genes.
Abstract: http://links.ealert.nature.
Article: http://links.ealert.nature.
Variants modulating the expression of a chromosome domain encompassing PLAG1
influence bovine stature pp405 - 413
Latifa Karim et al.
doi:10.1038/ng.814
Michel Georges and colleagues report fine mapping and functional characterization
of a quantitative trait locus with a large effect on bovine stature. They show
that the likely causal variants at this locus modulate expression of a
chromosomal domain encompassing PLAG1 and several other genes.
Abstract: http://links.ealert.nature.
Article: http://links.ealert.nature.
Glycerol-3-phosphate is a critical mobile inducer of systemic immunity in plants pp421 - 427
Bidisha Chanda et al.
doi:10.1038/ng.798
Pradeep Kachroo and colleagues show that glycerol-3-phosphate is a critical mobile
inducer of systemic acquired resistance in plants.
Abstract: http://links.ealert.nature.
Article: http://links.ealert.nature.
Mutant nucleophosmin and cooperating pathways drive leukemia initiation
and progression in mice pp470 - 475
George S Vassiliou et al.
doi:10.1038/ng.796
George Vassiliou, Allan Bradley and colleagues perform a Sleeping Beauty
transposon mutagenesis screen to identify insertions that cooperate with
mutant Npm1 to produce acute myeloid leukemia (AML) in mice. They observed
mutually exclusive integrations in Csf2, Flt3 or Rasgrp1 in a high percentage
of cases, providing insights into the molecular pathogenesis of this AML subtype.
Abstract: http://links.ealert.nature.
Article: http://links.ealert.nature.
A framework for variation discovery and genotyping using next-generation
DNA sequencing data pp491 - 498
Mark A DePristo et al.
doi:10.1038/ng.806
Mark DePristo and colleagues report an analytical framework to discover
and genotype variation using whole exome and genome resequencing data
from next-generation sequencing technologies. They apply these methods
to low-pass population sequencing data from the 1000 Genomes Project.
Abstract: http://links.ealert.nature.
Article: http://links.ealert.nature.
0 comments:
Post a Comment