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This new sixth edition of Burger's Medicinal Chemistry and Drug Discovery offers several new and unique features. For the first time, an online version of this major reference work will offer updated content from the print edition and easy access. For the first time, all volumes are structured entirely according to content and published simultaneously to provide broad coverage of medicinal chemistry and drug discovery for new or experienced medicinal chemists, biologists, pharmacologists and molecular biologists. This includes a current and global perspective of drug design, and drug development.With expanded content from 69 chapters to over 100 chapters, this sixth edition of Burger's Medicinal Chemistry and Drug Discovery includes more than 50% new material. An entire section has been dedicated to cancer research. Areas included are those at the foreground of life science including:* Proteomics* Genomics* Bioinformatics* Combinatorial Chemistry* High-Throughput Screening* Blood Substitutes* Allosteric Effectors as Potential Drugs* COX Inhibitors* Statins* High-Throughput Pharmacology* and More.The new sixth edition of Burger's Medicinal Chemistry and Drug Discovery is a Memorial Edition to Professor Alfred Burger who published this major reference work in the first edition as "Medicinal Chemistry" in two volumes in 1951. Dr. Burger's research focused on analgesics, antidepressants and chemotherapeutic agents. He is one of the few academicians to have a drug, designed and synthesized in his laboratories and brought to market. Dr. Burger's contribution to the fields of medicinal chemistry and drug discovery are well renowned and documented. He received the Louis Pasteur Medal of the Pasteur Institute and the American Chemical Society Smissman Award.
Content
VOLUME 1
Structure Based Drug-Design
History of Quantitative Structure Activity Relationships
Recent and Developing Trends in QSAR: From Data Analysis and Model Validation to Drug Design and Discovery
Molecular Modeling in Drug Design
Drug-Target Binding Forces: Advances in Force Field Approaches
Combinatorial Library Design, Molecular Similarity and Diversity Applications
Virtual Screening
Docking and Scoring Functions/Virtual Screening
Bioinformatics
Chemical Information Computing Systems in Drug Discovery
X-ray Crystallography Drug Discovery
Electron Microscopy of Biological Macromolecules
Design of Peptidomimetics
Approaches to the Rational Design of Enzyme Inhibitors
Chirality and Biological Activity
Structural Concepts in the Prediction of the Toxicity of Therapeutical Agents
Natural Products as Leads for New Pharmaceuticals
Analog Design
NMR and Drug Discovery
Mass Spectrometry and Drug Design
VOLUME 2
Combinatorial Chemistry and Multiple Parallel Synthesis
Highthroughput Screening for Lead Discovery
High Throughput Pharmacology
The Application of Recombinant DNA Technology in Medicinal Chemistry and Drug Discovery
Oligonucleotide Therapeutics
Therapeutic Agents Acting on RNA
Carbohydrate Based Therapeutics
Membrane Transport Proteins and Drug Transport
Allosteric Proteins and Drug Discovery
Receptor Targets in Drug Discovery and Development
Large Scale Synthesis
Principles of Drug Metabolism
Metabolic Considerations in Prodrug Design
Retrometabolism-Based Drug Design and Targeting
Drug Discovery: The Role of Toxicology
Drug Absorption, Distribution, and Elimination
The FDA and Regulatory Issues
Intellectual Property in Drug Discovery and Biotechnology
Nicotinic Acetylcholine Receptors
Physicochemical Characterization and Principles of Oral Dosage Form Selection
VOLUME 3
Cardiac Drugs: Antianginal, Vosodilators, Antiarrhythmic
Diuretics and Uricosuric Agents
Myocardial Infarction Agents
Endogenous Vasoactive Peptides
Hematopoietic Agents
Anticoagulatns, Antithrombotics and Hemostatics
Antihyperlipedemic Agents
Oxygen Delivery via Allosteric Effectors of Hemoglobin, Blood Substitutes, and Plasma Expanders
Sickle Cell Anemia
Iron Chelators and Therapeutic Uses
Thyroid Hormones and Thyromimetics
Male Sex Hormones, Analogs, and Antogonists
Anti-inflammatory Steroids
Female Sex Hormones, Contraceptives & Fertility Drugs
Fundamentals of Steroid Chemistry and Biochemistry
VOLUME 4
Peptide and Protein Hormones, Peptide Neurotransmitters, and Therapeutic Agents
Inhibitors of Gastric Acid Secretion
Chemokines and Cytokine Modulators
COX Inhibitors and Leukotriene Modulators
Agents Acting on Prostanoid Receptors
Retinoids
Vitamins
Life Style and Over-the-Counter Agents
Radiopaques
Microarrays and Gene Expression Profiling Applied to Drug Research
SNPs: Single Nucleotide Polymorphisms and Pharmacogenomics
Gene Therapy with Plasmid DNA
Insulin and Hypoglycemic Agents
VOLUME 5
Molecular Biology of Cancer
Synthetic DNA-targeted Chemotherapeutic Agents and Related Tumor-Activated Prodrugs
Antitumor Natural Products
Radiosensitizers and Radioprotective Agents
Synthetic Anti-angiogenic Agents
Future Strategies in Immunotherapy
Selective Toxicities
Drug Resistance in Cancer Chemotherapy
Antiviral Agents, DNA
Antiviral Agents, RNA (Viruses other than HIV), Orthopoxviruses
Rationale of Design of Anti-HIV Drugs
Organ Transplantation Drugs
Synthetic Antibacterial Agents
Lactam Antibiotics
Tetracyclines, Aminolycoside, Macrolide, and Miscellaneous Antibiotics
Antimycobacterial Agents
Antifungal Agents
Antimalarial Agents
Antiprotozoal Agents
Anthelmintic Agents
VOLUME 6
Andrenergics and Andrenergic Blocking Agents
Cholinergics
Anticholinergic Drugs
CNS Stimulants
Sedatives and Hypnotics
Anticonvulsants
Analgesics
Antidepressants
Antianxiety Agents
Antipsychotic Agents
Investigative Agents for use in Neurodegenerative Conditions
Therapeutic and Diagnostic Agents for Parkinson's Disease
Alzheimer's Disease: Search for Therapeutics
Cognition Enhancers
Drugs to Treat Eating and Body Weight Disorders
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